`CIRCULATION IN THE MODEL`

Notes:
1. The Chemical (Neuroendocrine) and Neural (Central Nervous) systems overlap.
(Indeed are the same.) They are separated in the model to show up some distinctly different triggers, pathologies and therapies. Separating them also enables questions to be asked.
2. Connections between the Chemical (Neuroendocrine) and immune system are not unique to MS. Multiple Sclerosis is only indicated in the model when the neural (CNS) System is involved.

1 Immune to Neural (CNS)
This connection is well documented

2 Neural (CNS) to Chemical (Neuroendocrine)
Demyelination, especially in the brainstem, cervical medulla and hypothalamus,
affect the neuroendorine system. (Brainstem inflammation affects the
neurotransmitters, especially e.g. Serotonin in the Raphe Nuclei and Noradrenalin.
[Damasio’s discussion (in Descartes’ Error) makes this a more global
phenomenon, affecting more than brainstem activity.])

and then switching direction:

4. Neural (CNS) to Immune:
[Inflammed stimuli: Rex’s term]

5. Immune to Chemical (Neuroendocrine)
[See Blalock, Immunol. Today 1994; 115(11) 504] e.g. Interleukin-1 to
Hypothalamus

6. Chemical (Neuroendocrine) to Neural (CNS)
A question to consider. It may be worth noting that some neurotransmitters (e.g.
Acetylcholine and GABA) have chemical similarities to Myelin.

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